Job Description

Xencor San Diego Office, San Diego, California, United States of America Job Description Posted Wednesday, August 6, 2025 at 7:00 AM Xencor is a public, clinical-stage biopharmaceutical company located in the Los Angeles area (Pasadena) and in San Diego. Our focus is developing high-potential XmAb bispecific T-cell engagers and additional engineered drug candidates that leverage our differentiated technology platforms, and we are advancing our pipeline toward clinical proof-of-concept decisions. Our goal is to create high-impact therapeutics for patients with cancer and other serious diseases. More than 20 XmAb drug candidates engineered with our technology are in clinical development, and three XmAb medicines have been marketed by partners. For more information, please visit We have an excellent opportunity for a Manager, Clinical Supply Chain to join our team. This position will be based out of our San Diego office and requires minimum of 2 days a week on-site. Summary: The Manager, Clinical Supply Chain position will manage Interactive Response Technology (IRT) and distribution activities in support of Xencor clinical trials. Responsibilities include Implementation and management of IRT systems across programs and distribution of biopharmaceutical clinical supply, comparators, and combination drugs as required. Position will ensure all clinical trials receive timely and adequate supply for patients in support of the company’s clinical studies. Job Duties: Coordinates upkeep of End-to-End Manufacturing Smartsheet; updates inventory; ensures accuracy of expiry; drives regular CMC meetings to review Manages distribution activities in support of clinical trials. Oversees all logistics issues related to shipments to individual sites and to regional Depots as required. Supports QP Release function with QA taking the lead in scheduling and documentation as required. Oversees Depots, provides input as to locations, operations, and logistics in support of clinical trials. Manages Returns and Destruction process for each Study. Updates Trial Master File (TMF) for each program as required. Resolves shipping excursions on a timely basis in collaboration with QA. Ensures IP is cleared for import/export as required with Regulatory team. Collaborates with CMC Drug Product and Supply Chain team regarding required CMC budgeting, timelines and/or similar matters to ensure a seamless flow of information and planning for the clinical study to the CMC program level. Develops effective supply strategies maximizing available inventory by location and shelf life while minimizing waste and potential obsolescence. Leads risk mitigation through detailed insight of IP, comparator, and combination drug supply and demand issues for programs of strategic importance, cost, and/or constrained supply. Adheres to all department and company-wide policies regarding conduct, performance, and procedures Supports Supply Chain Packaging and Labeling activities as required. Adheres to all department and company-wide policies regarding conduct, performance and procedures Performs other duties as assigned. Education/Experience/Skills: Position requires a Bachelor’s degree, preferably in Life Sciences, Business (Economics, Operations Management, Clinical Supply Chain Management, Clinical Trials Coordination) or Engineering and 6 year of related experience with at least 3 years of hands-on work experience in clinical supply chain management forecasting and planning for clinical studies within Clinical Supply Chain, Clinical Operations, Planning, Manufacturing, Quality, or other Supply Chain disciplines, preferably in the Biotechnology/Pharmaceutical industry. Also requires prior people and project management experience for bulk drug products, IMP, comparators, and/or finished goods. Position also requires : Strong knowledge of supply chain processes including internal and external alignment (IRT, manufacturing, quality, analytics, regulatory, finance, clinical operations). Working knowledge of cGMP’s as related to large molecule biopharmaceutical activities, familiar with US, EU, and global regulations applicable to investigational drugs and GCP regulations applicable to investigational product and supply. Flexibility and willingness to adapt to changing business environment influences by developing and adopting new strategies and tactics. Ability to think strategically and translate into actionable plans. Strong ability to collaborate and build strategic and tactical relationships with internal (clinical operations, quality, regulatory, etc.) as well as external (CDMO, CPO, storage sites, etc.) stakeholders. Strong budget management and financial analysis skills. Ability to lead process improvement activities, delivering business processes and/or technical solutions satisfying multiple sets of stakeholders. Strong planning, organization, and time-management skills to juggle needs of multiple teams and projects simultaneously. Ability to demonstrate good judgment in determining objectives and approaches to assignments. Excellent verbal/written communication and presentation skills, including ability to simplify what is complex and focus audience on key messages. Strong computer (Excel, Word, PowerPoint, Visio) skills. Experience with Clinical Demand Planning and Inventory management systems. Ability to demonstrate competencies applicable for job based on Xencor’s Leadership Competency Model Ability to effectively manage others through coaching and supervision, in accordance with company policies and practices. Ensures employee performance meets the organization’s expectations for conduct, productivity, quality, continuous improvement, and goal accomplishment. Physical, Mental and Environment Demands: The physical, mental and working environment demands described are representative of those that must be met by an employee to successfully perform the primary functions of this position. The working environment for this role includes working in a research laboratory which may involve running experiments and operating laboratory scale process equipment for sample and data generation. Occasionally, repetitive tasks, prolonged standing, and the use of PPE for handling hazardous and biohazardous materials may be required. See additional requirements for laboratory and research related jobs listed below. The physical demands when working in the office environment are normally associated with extended amounts of time sitting and using office equipment, including a computer, keyboard and mouse, which can cause muscle strain. While performing the duties of this job, the employee is frequently required to stand, walk and sit. Periodic light lifting of supplies and materials may apply. Specific mental demands for the position are listed above under requirements. In addition, mental demands for this position include: Ability to multitask without loss of efficiency or accuracy, including the ability to perform multiple duties from multiple sources. Ability to work and sustain attention with distractions and/or interruptions. Ability to interact appropriately with a variety of individuals including vendors, customers and clients. Ability to maintain regular attendance and be punctual. Ability to understand, remember and follow verbal and written instructions. Occasional travel may be required, including travel between Xencor’s Pasadena and San Diego offices. Work for this position is generally performed at Xencor’s worksite and requires full-time commitment. Expected Base Salary Range: $130,500 to $158,500 The actual salary will be based on the selected candidate’s qualifications, including skills, competencies, education and experience.Xencor offers a competitive total rewards package including 401k match, healthcare coverage, ESPP and a broad range of other benefits. In addition, this position will be eligible for an annual bonus and equity grant. For more information, please see . Americans with Disabilities Act (ADA) Statement The Company will provide reasonable accommodations (such as a qualified sign language interpreter or other personal assistance) with the application process upon your request as required to comply with applicable laws. If you have a disability and require assistance in this application process, please contact HR@xencor.com. To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable Accommodations may be made to enable qualified individuals with disabilities to perform the essential functions. Equal Employment Opportunity (EEO) Statement The Company is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender or gender identity, national origin, disability status, protected veteran status or any other characteristic protected by state or federal law. Xencor does not accept profiles or resumes from recruiting vendors without a binding written agreement. Any unsolicited submission of services and or resumes in no way creates an obligation or duty by Xencor, implied or otherwise. Xencor San Diego Office, San Diego, California, United States of America #J-18808-Ljbffr Xencor, Inc.

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